Radio Frequency IDentification(RFID) series Radio Frequency(RF) card has been applied widely because of its stability，reliability and easy operation features. Aiming at multiple protocols，such as ISO14443 protocol，ISO15693 protocol and Tag-it protocol，this study proposed a new type of circuit design based on Advanced RISC Machine(ARM) for the RFID series RF card reader. The data stream encryption was implemented by using peripheral device in the operation. The system composition，working principle and work flow were introduced. Then，the detailed circuit design of the RF network and encryption hardware were presented，and the test and analysis for the design were performed. The results showed that the circuit could accurately read, write and encrypt various types of card within effective range.